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January 3, 2026

Semaglutide vs. Tirzepatide: What's the Difference in GLP-1 Care?

A patient-friendly comparison of Semaglutide and Tirzepatide, including how they work and how clinicians think about options.

Semaglutide vs. Tirzepatide: What's the Difference in GLP-1 Care?

Summary

GLP-1 medications are often discussed in weight and metabolic health care. Two common options are Semaglutide and Tirzepatide. This overview explains the high-level differences in plain language, without getting into medical advice.

A simple comparison at a glance

Both medications are used under clinician guidance and are part of broader care plans. The main distinction is how they interact with receptors in the body.

Semaglutide: GLP-1 receptor agonist

Semaglutide primarily targets GLP-1 receptors, which are involved in appetite and blood sugar regulation. It has a long history of clinical use and is commonly discussed in weight-management care.

Tirzepatide: Dual-action (GLP-1 + GIP)

Tirzepatide targets both GLP-1 and GIP receptors. This dual-action mechanism is why it is often described as a next-generation option in metabolic health conversations.

How clinicians think about options

The right plan depends on individual health history, goals, and clinician judgment. Factors like prior experience, overall health, and tolerance are part of the decision-making process.

Key takeaways

  • Both are used under clinician guidance
  • Semaglutide focuses on GLP-1 receptors
  • Tirzepatide acts on GLP-1 and GIP receptors

If you're curious about which approach may be appropriate for your goals, a telehealth assessment can help clarify next steps.

Next steps

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Disclaimer

MANÜ Telehealth retains the right to recommend and collaborate with internal and/or external medical specialists for any patient. Rest assured, all patient information will be safeguarded in accordance with governing HIPAA rules and regulations. It's important to note that MANÜ Telehealth is not an internet pharmacy and does not dispense, ship, or distribute medications from our facility or website. Any and all medication prescribed by our doctors and/or associated medical professionals will be dispensed exclusively from a US 503A Pharmacy. All patients are expected to adhere to and follow all medical instructions and procedures provided by our doctors and should promptly contact us if they encounter any issues. Patients who are found to have submitted fraudulent information will be disqualified from participating in any health program offered by MANÜ Telehealth. Remember, any medication prescribed is solely intended for the patient's use and must not be transferred, distributed, modified, or used by any other individual(s). At MANÜ Telehealth, your health and wellbeing are our priority.

Semaglutide vs. Tirzepatide: What's the Difference in GLP-1 Care? | MANÜ Telehealth